オロット酸投与がマウスの抗体不安作用に及ぼす影響

概要

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In this study, we examined the effects of orotic acid on behavior in adult mice. Ten weeks old male ddY mice were fed experimental diet containing 0.5% or 0.05% of orotic acid. At the age of 15-17 weeks, several behavioral tests were performed. Mice fed 0.5% of orotic acid showed antianxiety effects in open-field test. Mice fed 0.05% of orotic acid showed enhanced memory retention in step-through type passive avoidance test. These results suggest that orotic acid may improve brain function and affect on behavior in mice.
2010-03-31