心拍変動1/fゆらぎの特性に関する研究 : 第2報疾患の影響およびQOLとの関係

概要

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We investigated the relation 1/f fluctuations in heart rate (HR) variability and QOL, and several disease. Ambulatory ECG was monitored in 150 patients of various ages who had various pathophysiological conditions (healthy volunteers, hypertension, cardiovascular disease (CAD), Parkinson's disease, hypokalemia, sudden cardiac death). In 60 healthy volunteers, the correlation between QOL, assessed by questionnaire, and 1/f fluctuations was studied. Sequential RR data were processed by fast Fourier transformation (FFT), and the slope of the regression line (log frequency-log power density) was examined as X of the 1/f fluctuation. In patients with hypertension, CAD, Parkinson's disease, hypokalemia, and sudden cardiac death, the slope was less negative. The slope for sudden cardiac death was most negative (0.6060 ± 0.276). The slope of 1/f showed a significant correlation with QOL (F; 8.87 p<0.01). These findings suggest that 1/f fluctuations of HR can serve as one index of intermediate cardiovascular control, QOL and prognosis in clinical cardiology.
東京女子医科大学の論文
1996-12-25