川崎病患児からのウイルス分離のこころみ(東京女子医科大学附属第二病院小児科開局30周年記念論文集)

概要

論文の詳細を見る
The cause of Kawasaki disease is yet to be determined. Detection of the virus in the patients in the acute stage was attempted as an approach to identify the cause for Kawasaki disease. Subjects of this study were 45 patients with Kawasaki disease who were within five days of the onset and have not received immunoglobulin therapy yet. The subjects were selected regardless of their age and sex. Thirty two samples taken from buccal mucosa membrane, 22 from peripheral lymphocytes and 13 from feces were employed for the investigation. An attempt for the detection of viruses in buccal mucosa cells is the first unique approach. Duplicated sampling was conducted on some patients. In this study, no presumably relevant virus was detected in any of the samples employed. However, HHV-6 was detected from eight samples of peripheral lymphocytes using the PCR method. Polio virus type I was detected from one feces sample and an unidentifiable virus from another feces sample. The polio virus was considered to have been due to a polio vaccine administered six days prior to the sampling. The latter is still being investigated under cultured condition at present. Although this trial terminated with a negative result, the virus can't be entirely denied as a trigger for the induction of Kawasaki disease if several epidemiological information is taken into consideration. Successive trial will be further made with a different sampling approach.
東京女子医科大学の論文
1997-07-30

川崎病患児からのウイルス分離のこころみ(東京女子医科大学附属第二病院小児科開局30周年記念論文集)

スポンサーリンク

概要

著者

関連論文

スポンサーリンク