進行胃癌におけるc-erbB-2, nm23 H-1/NDP Kinase, CD44 Variant Exons 8-10発現の臨床的有用性の検討

概要

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Immunohistochemical study for the expression of c-erbB-2, nm23 and CD44v8-v10 was examined in tumor specimens taken from 107 patients who underwent gastrectomy for primary advanced gastric carcinoma. The expression of both c-erbB-2 and nm23 was correlated with the differentiated stage of gastric carcinoma. The expression of c-erbB-2 was also significantly correlated with the degree of tumor invasion and venous permeation. However, the expression of these three molecules was not correlated with either the histologic stage or the presence of metastases. Twenty-four patients with c-erbB-2 positive tumor had significantly lower survival rate than 46 patients with no c-erbB-2 positive tumor did. The expression of both nm23 and CD44 v8-v10 expression was not associated with patient survival. No significant correlation was observed between c-erbB-2 expression and the incidence of recurrence. These results suggest that immunohistochemical study of c-erbB-2 expression in tumor tissue seems to be one of important prognostic indicators in advanced gastric carcinoma patients.
東京女子医科大学の論文
1998-09-25