肝ティッシュエンジニアリングにおける新展開 : シート工学を応用した新規肝再生治療(21世紀COE記念シンポジウム再生医療の最前線,東京女子医科大学学会第71回総会)

概要

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Recent success in the experimental and clinical hepatocyte transplantation has encouraged further challenges to investigate bioengineering hepatic tissue in vivo. Liver tissue engineering is an important step toward alleviating the need for donor organs for liver transplantation : yet many problems must be overcome including limited period of hepatocyte survival at extra-hepatic sites and the difficulty in the functional maintenance of engineered tissues. Recently, our laboratory has overcome these problems by several innovative approaches and succeeded in engineering functional hepatic tissues that stably persist in the long-term under mouse kidney capsule as well as mouse subcutaneous space. It is of note that our technology allows engineered liver tissues in mice to retain the full capacity for the regeneration in response to the regeneration stimulus originated from their own livers. Furthermore, we have created a novel technology to engineer 2-dimensional hepatocytes sheet under the culture condition and established an approach for liver tissue engineering by inserting the hepatocytes sheet into mouse subcutaneous space. Further integration of the tissue engineering, gene therapy, and cell transplantation technologies are particularly important for establishing liver tissue engineering as a new generation therapeutic modality.
東京女子医科大学の論文