病理診断アトラス(5) : 循環器系1:心臓-心筋症を中心に

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Cardiomyopathies are defined as diseases of the myocardium associated with cardiac dysfunction. As previous definitions and classifications of cardiomyopathy were not necessarily complete, a new definition and classification were established by WHO and the World Heart Federation in 1995. Cardiomyopathies are classified as dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and specific cardiomyopathy, all of which are heart muscle diseases associated with specific cardiac or systemic disorders, including myocarditis, Fabry disease, amyloidosis and sarcoidosis. In the present paper, pathological characteristics of cardiomyopathies are described. Additionally, histopathologic aspects of cardiac biopsy after heart transplantation, which is one of the effective surgical treatments for end-stage cardiomyopathies are also reported. The most reliable method for the evaluation of acute rejection after transplantation is a histopathological diagnosis based on tissue obtained by endomyocardial biopsy from the recipient of the transplanted heart. The histopathological grading system (grade 0～4) of rejection in heart transplantation was established by the International Society for Heart Transplantation. An endomyocardial biopsy is useful for the diagnosis of cardiomyopathy, but also important for the evaluation of rejection after heart transplantation.
東京女子医科大学の論文