脳血管障害の遺伝子治療と新規治療の開発

概要

論文の詳細を見る
Stroke is a leading cause of death and disability in Japan, and a potential candidate for gene therapy. Several experimental studies have revealed the usefulness of gene therapy against ischemic neuronal damage. We have shown that the transfer of protective genes, including midkine, dominant negative MCP-1 and interleukin-10, have significantly reduced the infarct size even when the treatment was initiated after the ischemic insult. Furthermore, we have found that interleukin-23 and interleukin-17 play crucial roles in post-ischemic inflammation and the evolution of brain infarction. Such treatment to protect neurovascular units appears to be one direction for acute stroke treatment, and these molecular approaches would develop novel therapeutics for stroke.
福岡歯科大学学会の論文
2009-12-30