HISTOCHEMICAL STUDIES ON THE SURFACE OF THE TROPHOBLAST : PART 1. HISTOCHEMICAL STUDIES ON THE SURFACE OF NORMAL AND SPONTANEOUSLY ABORTED HUMAN TROPHOBLAST

概要

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The surface coating of normal and spontaneously aborted human trophoblast has been studied histochemically. The colloidal iron reaction on the spontaneously aborted trophoblast cell was weak or almost totally absent as compared with that on the normal trophoblast cell. The reaction was scarcely visible on the cell surface of the neuraminidase-treated trophoblast. These findings suggest that the material on the cell surface of the trophoblast is characterized as a muciprotein rich in sialic acid and some spontaneous abortions are the result of immunological rejection caused by the breakdown or the defect of the mucoprotein of the trophoblast cell surface. In histochemical studies of the deciduotrophoblastic junctional zone, the Prussian blue reaction was observed on the trophoblast cell surface of normal pregnancies but not present on that of spontaneous abortions. There was no deposit on the fibrinoid layer at all. These findings suggest that the mucoprotein coating of the surface of the trophoblast is of importance in the protection of the trophoblast against maternal immune reaction as compared with the fibrinoid layer of the deciduotrophoblastic junctional zone.
名古屋市立大学の論文
1977-08-28