下部直腸癌における側方リンパ節郭清の検討(特別講演IV,第152回名古屋市立大学医学会例会)

概要

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Background:For rectal carcinoma, the presence of lateral lymph node metastases may be the most useful prognostic factor. This study was designed to identify the lateral lymph node dissection is benefit for prognosis. Materials and method:The study involved 77 rectal carcinoma patient below the peritoneal reflection from 1994-2003. We studied their clinicopathological factors retrospectively. And 45 samples were analyzed immunohistochemically using antibodies to the following antigens:SLX, SLA. The expression of these factors was compared with clinical features, and data were analyzed using the Cox proportional hazards regression model, Kaplan-Meier survival curves, and the Wilcoxon test. Result:The lateral lymph node dissection is benefit for local control, not for prognosis. There was a statistically significant association between lymph node matastasis and strong expression of SLX (P=0.02). FUrthermore, there was a significant correlation between strong intensity SLX expression and poor prognosis in patients with lower rectal cancer. Discussion:The expression of SLX may be a good biological maeker, predictive of postoperative prognosis in lower rectal cancer.
名古屋市立大学の論文
2008-07-01