IMMUNOHISTOCHEMICAL ANALYSIS OF ANGIOGENIC FACTORS IN NON-SMALL CELL LUNG CANCER

概要

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It has been well known that angiogenesis plays an important role in tumor growth. However the relationship between lung carcinoma and angiogenic factors remains unclarified. The present study was undertaken to conduct immunohistochemical evaluation of factors possibly related to angiogenesis, i.e. endostatin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in surgical specimens from 83 patients with non-small cell lung carcinoma and to analyze their relationship to clinical features and prognosis of patients with this cancer and the effects of these factors on angiogenesis. Staining score (SS) was employed for each immunohistochemical evaluation. A positive correlation was noted between VEGF SS and pT factors (maximal diameter of tumors). In lung cancer tissue, endostatin was found to be involved in suppression of angiogenesis, while VEGF and bFGF was found to stimulate angiogenesis. The Degree of involvement of each of these three factors in angiogenesis in lung cancer tissue was expressed by a coefficient unique to each factor. Although no correlation between sngiogenic factors and the prognosis of patients with this cancer was found in the present study, the results suggest some relationship between lung cancer tissue and each angiogenic factor.
名古屋市立大学の論文
2008-03-31