香料の安全性評価に対する毒性学的懸念における闘値概念の有用性

概要

論文の詳細を見る
Threshold of toxicological concern(TTC) concept has been applied by JECFA which was established by the cooperation of FAO and WHO and it is the method to evaluate the toxicity of environmental chemicals and to determine human exposure threshold value by the chemical structures and the reliable exposure estimates which does not affect the human health. The characteristics of flavoring substances are often the components of usual food, known chemical structures, very low dose exposure, and the lacking toxicological data of many of them. TTC concept has been utilized for the risk assessment of flavoring substances in U.S. and Europe and the decision trees for the assessment process are different between Japan and U.S. or Europe. Now-a-days, great attentions have been paid by consumers to the safety of food containing flavoring substances and therefore, it is important issue to supply the exact knowledge for the safety of flavoring substances per se to the consumers. In this paper, it is discussed that the test systems of flavoring substances for risk assessment by collecting useful information internationally. It is considered that the risk assessment of flavoring substance might be performed in the different way from that of other environmental and intended to be proposed decision tree using TTC concept for flavoring substances.
日本食品化学学会の論文
2008-08-20