感作ウサギにおける骨と骨髄の態度
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A histopathological study of bone and bone marrow in prolonged sensitization induced in 30 rabbits by repeated intramuscular injections of egg-white, egg albumin-, and bovine serum albumin-liquid paraffin Arlacel emulsion treated with ultrasonic wave procedure or intraparanasal and intravenous injections of egg white, and horse serum is presented. The study has revealed that serous exudation or seroexudative-histolytic reaction of the angibmesenchymal tissue of bone and bone marrow followed by hyperplasia of myeloid tissue as well as its extension to bone tissue, or myeloid metaplasia of the angiomesenchymal tissue of bone takes plase following the antigenic stimulations. The aforementioned process becomes manifest in the course of prolonged and repeated antigenic stimulations. In the later or terminal stage, hyperplasia of myeloid tissue subsides and falls into exhaustion, i. e., atrophy or mild fibrosis (one rabbit, 322 experimental days). In some instances, however, marked hyperplasia accompanied with structural alteration ("Splenoides Mark") is followed by fibrillosis and fibrosis even in the earlier stage (4 rabbits, 39, 108, 120, and 236 days). Extensive or pathy inflammatory exudation and following fibrosis also appear in the course of prolonged sensitization (6 rabbits, 40, 83, 114, 118, 164, and 232 days). Besides these fibrosing processes, there occures focal fibrosis in the organization of anemic infarction of bone and myeloid tissue due to thrombotic angitis (4 rabbits, 80, 95, 160, arid 238 days). The processes mentioned above take place both in bone and in bone marrow and eventually bring about a picture of osteomyelofibrosis as a result of the collaboration of various processes (5 rabbits, 80, 83, 114, 160, and 238 days).
- 千葉大学の論文
- 1963-01-28
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