感作ウサギにおける腎臓の態度
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概要
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A histopathological study of renal lesions induced in rabbits by prolonged sensitization with or without some additional experimental procedures is presented. First, renal changes of 96 rabbits which received repeated and prolonged injections of egg white or egg white-liquid paraffin emulsion prepared by ultrasonic wave procedures for less than 515 days were examined histologically. This study revealed that various renal lesions such as glomerulitis (glomerulonephritis), glomerular, tubular, and vascular amyloidosis, crescent formation, various degenerative changes and atrophy of tubular epithelium, interstitial nephritis, myeloid metaplasia, thrombosis of arterioles and capillaries, pyelitis and pyelonephritis, etc. appeared in the course of prolonged sensitization. From this study it has been suggested that there are varied tissue manifestations of glomerulitis following the couse of prolonged sensitization, i.e., proliferative-fibrosing or -sclerosing glomerulitis occurs in the earlier stage of sensitization, while degenerative glomerulits or glomerulitis characterized by fibrinoid or fibrinoid-hyaline degeneration of loop walls takes place in the later stage (after 200 experimental days). Renal amyloidosis and myeloid metaplasia were also events not infrequently encountered after 100 experimental days. Secondly, Masugi nephritis induced in rabbits by intravenous injection of anti-rabbit-kidney duck serum into rabbits which had previously been sensitized with foreign proteins was studied. In this study renal lesions were studied with repeated wedge shaped biopsies of kidneys. Three rabbits which received injection of anti-rabbit-kidney duck serum on the 41st day of sensitization with duck serum euglobulin developed glomerulonephritis with a tendency to healing as was the case in Masugi nephritis in nonsensitized rabbits. Following injection of anti-rabbit-kidney duck serum into 3 rabbits which had been sensitized with egg white for 56 days prolonged glomerulonephritis in which serum protein fractions developed nephrotic patterns during the course was induced in contrast to the occurence of glomerulonephritis terminated in healing in the control animals which received injection of anti-rabbit-kidney duck serum only. Thirdly, degenerative glomerulitis was induced by means of intraabdominal administration of the own or/and homologous kidney emulsion into 2 rabbits which had been sensitized with egg white-liquid paraffin for 162 or 165 days. In this experiment fluoresceint antibody technique revealed that globulin was present in the thickened glomerular loop walls with fibrinoid degeneration in the residual kidney of a test animal. Moreover, reactive globulin against homologous kidney was also demonstrated to be present in the serum of this rabbit by the same procedure. The experimental results here obtained has strongly suggested that tissue manifestations of glomerulitis in the sense of glomerulonephritis is intimately related to the immunohematological or -chemical state or its disorders in the course' of prolonged sensitization with foreign proteins.
- 千葉大学の論文
- 1963-01-28
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