消化器癌患者における血中癌細胞について
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In 78 patients with digestive tract carcinoma and 34 controls, cancer cells in the blood stream were investigated in the blood obtained from the ante-cubital vein and regional vein closing to the lesions, and the incidence of positive cancer cells in the blood stream were comparatively studied in relation to. clinico-pathological findindings. In this study, cancer cells were isolated from the other cells in the blood stream by accelation erythrocyte sedimentation adding polyvinyl-pyrrolidon (average molecular weight 700,000) and stained by Giemsa, May-Griinwald-Giemsa and Peroxydase's technique. Cancer cells in the blood stream were identified by the author's cytologic criteria modified from Papanicolaou's criteria. 1) In the blood of 78 patients with carcinoma, 98 single cancer cells and 23 clumps of cancer cells were observed. Identification of cancer cells were easier in clumps than single cells. 2) The incidence of positive cancer cells of the blood stream.was lower in the blood obtained from the ante-cubital vein (15.8%) than in the blood obtained from the regional vein closing to the tumor (27.9%) and in the blood obtained from the ante-cubital vein of the patients with primary lung cancer (21.7%). 3) In most patients with cancer cells in the blood obtained from the ante-cubital veins, radical removal of the cancer was impossible. The cancer cells floating in the ante-cubital veins were considered to be related to metastatic cancer cells in the lung. 4) The incidence of cancer cells in the blood stream was higher in those with advanced cancer, especially with hematogenic or lymphogenic metastasis than those with early cancer without metastasis. The incidence of cancer cells in the blood stream was high in those with larger size of tumor or those with infiltrating type of cancer than those with small or localized tumor. 5) According to Prof. Takizawa's classification, the incidence of cancer cells observed in the regional vein was the highest in carcinoma simplex, next adenocarcinoma with solid structure and the lowest in typical adenocarcinoma. 6) The incidence of positive cancer cells in the blood stream was not influenced by surgical manipulation, but the number of cancer cells was markedly increased by surgical manipulation in some cases. In patients with cancer and cancer cells in the blood stream, investigation of further metastases such as hematogenic or lymphogenic metastases of cancer to the lung or liver, rapid ligation of the veins during operation and chemotherapy with anti-cancerous agents were highly recommended.
- 千葉大学の論文
- 1961-07-28
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