腎疾患に於けるNa^<24>域,全体Na量について

概要

論文の詳細を見る
By using radioactive sodium (Na^<24>), sodium space and total exchangeable sodium (Nae) were measured 53 times in 46 cases of renal and other diseases as well as normal persons. 1. Values obtained in normal persons were as follows : Na^<24> space, 10.02±0.82 1/m^2 ; Nae, 1412.6±212.73 mEq/m^2. 2. In renal diseases, it took 20 hours for intravenously injected Na^<24> to equilibrate in the body, irrespective of whether there was edema or not; but in hepatic cirrhosis, it equilibrated within 15 hours. 3. Na^<24> space and Nae were increased in edematous patients, and they were increased in some of them immediately before and after the manifestation of edematous symptoms also. 4. Plasma sodium concentration tended to decrease in edematous Nae increased patients, returning to normal range with the normalization of Nae levels. 5. Renal tubular reabsorption rate of sodium (TRF_<Na>) was decreased in patients whose Nae/GFR values were markedly increased. This seems to indicate a renal mechanism designed to maintain the stability of sodium content in the body. In nephritic patients with normal hydration and decreased TRF_<Na>, it may not be said that they are wasting sodium to excess, for they showed no decrease of Nae below normal levels.
千葉大学の論文
1960-11-28