千葉県八日市場地方に於ける鉤虫感染の場に関する知見 : 第1編 特に人体感染実験について
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概要
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Experiments were carried out in 42 year old male, whose stools were negative for hookworm eggs and did not produce larvae by kawara culture method, to study the ability of hookworm larvae to gain entrance into human body by the skin. 145 larvae of Necator americanus were placed on the dorsal surface of the left hand, and 108 larvae of Ancylostoma duodenale on the dorsal surface of the right hand. After the larvae had been left free to act on the skin for, one hour, the skin was rinsed with water and the numbers of larvae collected in the water were counted. By deducting the numbers of the larvae retrieved from the water from those initially placed on the skin, 117 larvae of N. americanus and 65 larvae of A. duodenole were estimated to have penetrated. The results were summarized as following. 1. In 17 minutes after the larvae of N. americanus were placed in contact with the skin, there occurred formication and slightly painful itching at the site of infection. The latter gradually grew in intensity and, after reaching the highest level on the fourth day, tended to subside thereafter, disappearing completely on the fifteenth day. 2. In 1 hour after the larvae of N. americanus were placed in contact with the skin, there appeared a round red patch, 6×5 mm. in size, at the site of infection. It grew in size and the condition was the most marked on the fourth day. Since then, it gradually decreased in size and was reduced to a pink papule as large as a millet on the fifteenth day. On the twentysecond day there only remained a pink spot, and by the thirtieth day an entirely normal state had been restored to the skin at the site of infection. 3. Systemic symptoms consisted of malaise and chills appearing on the third day of infection and lasting only a few hours. 4. There were neither subjective symptoms nor macroscopical changes in the skin with which the larvae of A. duodenale were placed in contact. 5. It was not until the sixtieth day of infection that the stools produced the larvae of N. americanus on culture by Kawara method. They were negative for A. duodenale on culture by the same method. Subsequent tests were .only positive for N. americanus. 6. Though 117 larvae of N. americanus were estimated to have entered the body, the number of worms expelled were 12 in total (3 males and 9 females). The ratio of the number of worms expelled to the number of larvae that entered the body was 12:117, or 10.2 per cent. No worms of A. duodenale were expelled.
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