Polyvinylpyrrolidoneの薬理 : (2) Chlorpromazineの脳組織呼吸におよぼす影響にたいする併用効果
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(1) The influence of chlorpromazine CCP), caffeine and amphetamine on respiration of the brain tissue was studied in the mouse. The combined action of each of these drugs with polyvinylpyrrolidone (PVP) was also studied. The results of these experiments were compared. (2) PVP, when given subcutaneously, did not cause any change in the consumption of oxygen (Qo_2) by various portions of the brain tissue. When it was added to various portions of the brain tissue incubated in test tubes, they showed a decrease in oxygen consumption. (3) CP, when given subcutaneously or added to various portions of the brain tissue incubated in test tubes, caused the oxygen consumption by them to decrease, the diencephalon showing the greatest reduction in Qo_2, followed by the mesoencephalon and medulla oblongata in that order. When CP was given in combination with PVP by subcutaneous injections, the decrease in oxygen consumption was smaller in amount but lasted for a longer duration than when CP was given by itself. When CP in combination with PVP was added to various portions of the brain tissue incubated in test tubes, the decrease in their oxygen consumption was more marked than when CP was used singly. (4) Caffeine and amphetamine, when given subcutaneously or added to various portions of the brain tissue incubated in test tubes, caused an increase in Qo_2. The cortex of the cerebrum showed the largest increase in Qo_2, followed by the medulla oblongata and mesoencephalon, when caffeine was administered. When amphetamine was given, an increase in Qo_2 was most marked in the diencephalon and cortex of the cerebrum. When these drugs were given in combination with PVP, Qo_2's of various portions of the brain tissue were not much larger in subcutaneous injections but were smaller in incubation tests than when each of them was given singly. (5) Caffeine and amphetamine exerted an inhibitory action against CP, so far as their effects on body temperature and Qo_2 were concerned.The administration of PVP in combination with one of these drugs caused their action more or less to be weakened. (6) Consecutive subcutaneous injections of CP caused the body temperature to fall to a level around 37℃ in about 8 days; continuation of injections did not cause a further fall at that point. There was no appreciable change in Qo_2's of various portions of the brain tissue between the mouse under study and the mouse to which physiologic saline was given, which served as cpntrols. There was no change in weight between them, either. The administration of PVP in combination with CP did not have any effects on the action of CP.
- 千葉大学の論文
- 1959-03-28
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関連論文
- Polyvinylpyrrolidoneの薬理 : (1) 二,三薬物との併用効果
- Polyvinylpyrrolidoneの薬理 : (2) Chlorpromazineの脳組織呼吸におよぼす影響にたいする併用効果
- Polyvinylpyrrolidoneの薬理-1・2-