Phenothiazine誘導体の中枢作用に関する薬理学的研究 : とくに麻酔作用並びに体温におよぼす影響について

概要

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Of all the derivatives of phenothiazine, 4560 R. P. has a specific action and has been arousing attention as a drug capable of inducing artificial hibernation. The author conducted experiments on the influences of 3015 R. P., 2987 R. P. and 4560 R. P. on bodytemperature as well as on the anesthesia induced by ether or barbiturate. The test on their possible relation with pendiomide, an autonomic blocking agent, was also performed. (1) Of the phenothiazine derivatives used for experiments, 4560 R. P. had the strongest action to cause a fall of body temperature and to potentize anesthetics, followed by 2987 R. P. and 3015 R. P. in the indicated order. (2) The action of the derivatives of phenothiazine under consideration to potentize anesthetics was more marked when used with methyl hexabital than when used with ether. (3) The influence of the derivatives of phenothiazine under consideration on the anesthetizing action of methyl hexabital varied with the change in atmospheric temperature : they potentized the anesthetizing action moderately in high temperature and markedly in low temperature. (4) The action of the derivatives of phenothiazine under study to lower.body temperature paralleled their action to potentize anesthetics. (5) Pendiomide was shown to have an action of lowering body temperature. When used in large doses, it lengthened the duration of anesthesia induced by methyl hexabital.
千葉大学の論文
1959-01-28