Phenothiazine誘導体の中枢作用に関する薬理学的研究 : とくに大脳皮質除去動物におけるChlorpromazineの作用

概要

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Chlorpromazine has been shown to have a specific action on the brain center. The author made studies on its effects on leukocyte count and body temperature in decorticated animals. The results are summarized as follows : (1) The administration of chlorpromazine to normal animals resulted in a decrease in leukocyte count and a fall in body temperature. This action of chlorpromazine was potentized when phenobarbital was administered in combination with chlorpromazine. (2) The state of violent sham rage was induced,in. rabbits in a few hours following decortication, with the result that the decorticated rabbits could not survive long. The administration of chlorpromazine relieved this state. (3) Leukocyte count and body temperature of rabbits have remained normal even after they were decorticated. (4) Studies have been performed on decorticated cats over a long period of time. The state of sham rage was induced by the administration of physiologic saline 3 to 7 hours after decortication. An increase in leukocyte count occurred simultaneously. The administration of chlorpromazine to decorticated cats during this period did not induce a state of sham rage, but caused a decrease in leukocyte count and a fall in body temperature.
千葉大学の論文
1959-01-28