滲濾出機転に関する実験的研究
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For the purpose of clarifying the factors involved in the phenomenon of exudation and transudation, the author injected a toxic solution as well as several solutions having different osmotic pressures into the pleural cavities of rabbits, and examined both systemic and local reactions to the stress in terms of water, salt, sugar and protein metabolisms. The results are summarized as follows (1) Both local and systemic reactions of the rabbits injected with an isotonic salt solution were moderate in degree, and the solution was gradually absorbed and excreted in the urine, maintaining Donnan equilibrium with the serum. In the rabbits injected with an isotonic glucose solution, the transudat passing through the pleura gradually increased in amount, while intracellular dehydration which first occurred as a systemic phenomenon gradually gave way to extracellular dehydration. (2) Rapid and profuse transudation occurred simultaneously with exudation in the rabbits injected with hypertonic solutions. Injections of a hypertonic salt solution caused intracellular dehydration followed by death in many rabbits, while injections of a hypertonic glucose solution resulted in extracellular hypotonic dehydration. (3) Strong transudation and exudation suddenly occurred in the rabbits injeted with a hypotonic solution (distilled water). Hypertonic dehydration characterized the rabbits capable of urination, while those incapable of urination died of hydremia. (4) Systemic reactions of the rabbits injected with a toxic solution (an aqueous solution of formic acid) were in direct proportion to its concentration; when a solution of higher formic acid content was used, exudation occurred earlier and the protein content of exudation was higher than was the case with a solution of lower formic acid content. To sum up, different kinds of stresses to which the rabbits were subjected by the injections of different kinds of solutions into their pleural cavities caused varying degrees of systemic as well as local reactions, which varied in intensity from simple transudation to complicated exudation, until a new state of balance had been reached. These reactions could be understood as manifestations of defense mechanism by which a body spontaneously functions to maintain homeostasis.
- 千葉大学の論文
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- 滲濾出機転に関する実験的研究