ビタミンB_1・肝機能・尿沢田反応・尿ビルビン酸・チセリウスの関係

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Vitamin B_1 plays an important role in the metabolism of carbohydrates. Birbic acid is formed as an intermediary product of the metabolism of sugar and is converted into acetaldehyd and carbon dioxideby the catalyzing action of co-carboxylase. The disturbance in liver function is often noticed in cases of disorder of the metabolism of birbic acid as well as of vitamin B_1 deficiency. The author carried out experiments in about 100 each of normal and tubercular persons to see if there are any relations between the metabolism of vitamin B_1, the metabolism of birbic acid and the liver function. The statistical analysis of the results is givenbelow: (1) There was correlation between vitamin B_1 deficiency and the disturbance in liver function revealed as the results of BSP test, Takada's test and the tests for urobilin and urobilinogen in the urine. There was closer relation between vitamin B_1 deficiency and the disturbance in excretory function as revealed by Takada's test and the tests for urobilin and urobilinogen in the urine, than between _vitamin B_1 deficiency and the disturbance in metabolic function as revealed by BSP test. (2) There was correlation between the results of Sawada's urinary test and the disturbance in liver function. The association of the latter with the former was found to be the highest in the results of the test for urobilinogen in the urine, followed by those of Takada's test, the test for urobilin in urine and B S P test in the indicated order. (3) There was correlation between the results of Sawada's urinary test and vagotonia. It would, however, going too far to say that the positive results of Sawada's test in the cases of vagotonia indicate the presence of vitamin B_1 deficiency in the broad sense of the word. (4) In the group which included the cases of liver function disturbance and vagotonia, there was correlation between the results of Sawada's urinary test and those of vitamin B_1 administration test. This correlation was not found in the group which did not include the cases of liver function disturbance. The association between the results of these two tests was higher in the group which did not include the group which included the cases of liver function disturbance. (5) There was no correlation between the quantity of birbic acid excreted in 24 hours and vitamin B_1 deficiency. (6) There was no correlation between the quantity of birbic acid excreted in the urine in 24 hours and the disturbance in liver function. However, the association of the latter with the former was found to be the highest in the results of the test for urobilinogen in the urine, followed by those of the test for urobilin in the urine, BSP test and Takada's test in the named order. (7) There was no correlation between the quantity of birbic acid excreted in the urine in 24 hours and the results of Sawada's urinary test. There occurred an increase in the quantity of of birbic acid only in the group to which the extract of capsules had not been administered, and the cases in which the increase had occurred were all positive for Sawada's urinary test. The increase in the quantity of pyruvic acid excreted in the urine would, therefore, be attributed to vagotonia. (8) The changes in total protein and gamma globulin levels were most closely related to vitamin B_1 deficiency. (9) Of all the tests for liver function, Takada's test produced sesults which corresponded most closely to vitamin B_1 deficiency in total protein and gamma globulin levels. Significant difference in albumin fraction level and the ratio albumin/globulin between liver function disturbance and vitamin B_1 deficiency was found in the results of Takada's test alone,. The group consisting of cases positive for Takada's test showed a rise in gamma globulin level, while the group consisting of cases of vitamin B_1 de ficiency showed a lowering in gamma globulin level.
千葉大学の論文
1957-01-28

ビタミンB_1・肝機能・尿沢田反応・尿ビルビン酸・チセリウスの関係

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