ヨーグルトの作用に関する実験的研究 : 第1編 動物成長に及ぼす影響に就て

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概要

• 論文の詳細を見る

• In 1908, Metchnikoff advanced a theory that yoghurt, which contains Lactobacillus, is effective in preventing senilism and artery hardening, thus contributing of prolongation of life expectancy. Since then, it has been widely believed that, when Lactobacillus is orally administered, acid production generated by its multiplication would increase hydrogen ion concentration and lessen the growth of pathogenic organisms, especially putrefactive organisms, in the intestines, and would affect the living body favorably. There has recently been manifested an increased interest in the medicinal as well as nutritive value of yoghurt in connection with popularization of Hauser's diet. However, the mechanism of action invalued has not been clarified yet ; its influence on the efficacy of antibiotics and its nutritive value for children are among the problems that remain to be elucidated. As part of a series of studies on intestinal bacterial flora carried out in our department, the author performed an investigation on the effect of yoghurt on intestinal bacteria. Young and healthy male mice were divided into 4 groups, and the first group was fed on Morinaga's yoghurt (containing L. bulgaricus), the second group on whole milk and the third group on skim milk in addition to the basal diet, while the fourth group was fed on basal diet alone. The numbers of L. acidoph., Enteroc. and Esch. coli in the feces were used as a yardstick for comparing the effects of diet ; the numbers of Enteric. and Esch. coli were computed by a modification of M.P.N. method originated by McCardy in accordance with the table of Homma and Tato, while the number of L. acidoph. was determined after the organisms had been incubated in Homma's mediums for 6 days at 37℃ by anaerobic culture (Verney's method). The results of the experiments are summarized as follows: 1) In the first and second groups, L. acidoph. was always the most numerous, with an average of 109 per 1 g of feces, while the number of Esch. coli paralleled that of Enteroc., both being in the range of 10^5-10^6 per 1 g of feces. 2) In the third and the fourth groups, either L. acidoph. or Esch. coli was the mostnumerous by turns, both being in the range of 10^8-10^9 per 1 g of feces, while the number of Enteroc., always the smallest with a range 10^5-10^7, did not parallel that of Esch. coli. 3) The first group gave the largest number of normal fecal discharges. This seems to reflect yoghurt's action of improving intestinal disorder. It was followed by the groups 2,3 and 4 in the indicated order. 4) The largest increase in body weight was shown by the first group, though the increase was not so conspicuous as compared with other groups. Increase in Body Weight(in per centage) [table] 5) Hydrogen ion concentration. of the feces varied in the individual mice.

• 千葉大学の論文
• 1957-01-28

著者

• 安藤 良夫

  千葉大学医学部衛生学教室

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• 7. ヨーグルトの動物成長に及ぼす影響について(I.一般演説,谷川教授開講十周年記念,第329回千葉医学例会,衛生学教室例会連合会演説要旨)

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