第2篇 疫痢,赤痢患児の腸内菌叢に及ぼす抗生物質投与の影響
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The author carried out experiments in an effort to evaluate the influences the administrationofantibiotics would have on the numbers of intestinal bacteria in infants and children suffering from ekiri and dysentery. The results are summarized as follows: (1) When antibiotics (aureomycin and chloromycetin) were administered separately, the bacteria of the genus Shigella were suddenly diminished in number and reduced to nil on the third day, while the number or coliform germs was reduced to nil on the third day after showing a mild increase on the first or the second day. The number of enterococcus germs reached the lowest level on the third day but began to multiply on the fourth day. (2) Combined administration of antibiotics (streptomycin and aureomycin; streptomycin and terramycin) brought about similar results as a separate administration of each antibiotic, except that the number of enterococcus germs showed a tendency to increase earlier in combined administrations than in separate one. A similar tendency was also manifested in the distribution of microorganisms. (3) On the fourth or the sixth day after the institution of the administration of antibiotics, a phenomenon of bacterial turn-over was evidenced in pathogenic microorganisms that are mildly poisonous, such as micrococcus, Paracoli and Proteus germs. It was observed that a decrease in the number of the bacteria of the genus Shigella paralleled an improvement in the . conditions of patients and a disappearance of mucus in the stools. The above findings show that the treatment of ekiri by antibiotics would require an institution of the treatment at the early stage of. the disease and that, in the treatment of dysentery, the administration should be continued for at least five days. Combined administration would not result in the enhancement of the effect, though it would possibly prevent the germs from becoming resistant to drugs. When the administration is to be carried on for morethan, a week, attention should be paid to the occurrence of complications due to the phenomenon of bacterial turn-over.
- 千葉大学の論文
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- 第2篇 疫痢,赤痢患児の腸内菌叢に及ぼす抗生物質投与の影響
- 第1篇 疫痢,赤痢患児の腸内菌叢の研究