放射性同位元素P^<32>に依る循環血球量測定に関する研究
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概要
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The most reliable method available at the present time for determining the blood volume in circulation is to measure the erythrocyte volume and the plasma volume separately, the former by means of radioactive isotope P"2 and the latter by means of T-1824 dye method, and then obtain the sum of two values. However, there remains much to be desired in the way of improving the method in which P^<32> is used for the determination of erythrocyte volume in circulation. The author has carried out exhaustive examination of the method in persons, rabbits and dogs from December, 1951 to March, 1954 in the clinic. The problems were divided into: (1) those that arise prior to the injection of tracer red cells and (2) those that occur after the injection. After developing a method and technique of our own as the results of the examination, clinical investigations were performed on 33 cases (5 cases of normal persons, 9 cases of cardiac troubles, 12 cases of kidney troubles and 7 cases of other diseases) and the volumes of blood, erythrocyte and plasma were measured by a combination of the two methods, the method developed by us using P^<32> and T-1824 dye method. The determination of erythrocyte volume by means of P^<32> involves the following disadvantages that might cause error in the results of the experiments: (1) P^<32> tends to disengage itself from the red cell and escape into the physiological saline, and (2) the hemolytic red cell has inhibitory action upon radioactivity of the sample. Generally speaking, the erythrocyte volume determined by T-1824 dye method is larger than that measured by a method in which P^<32> is used, but the ratio of the two is not constant; it seems that, in cardiac and kidney troubles, the value measured by t-1824 dye method is far larger than it actually is.
- 千葉大学の論文