急性催眠剤中毒の臨床的研究
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概要
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This report concerns 70 patients admitted to the Chiba National Hospital on account of hypnotic poisoning during the period of six years from 1949 to 1954. Most of them have ingested "brovarin" (bromvalerylures) or "adorm" (cyclobarbital), and of these patients nine died. Examinations of temperature, blood picture, plasma protein, blood sugar, and liver and kidney functions were performed in these patients. The results are summarized as follows: (1) In 47 cases (or 68 percent), the temperature rose to 37.5-41.3℃ within 48 hours after the onset of the coma. (2) Erythrocyte and hemoglobin contents of the blood showed an increase during the comatose stage, due mostly to the hemoconcentration due to plasma loss. (3) At the same time, leucocyte count increased markedly as the result of neutrophilic leucocytosis. After the 3 rd day, however the number of leucocyte tended to fall below normal. On the other hand neutrophilia was usually accompanied by lymphopenia and eosinopenia. (4) Plasma protein, particularly albumin-concentration, was gradually decreased after about 24 hours' latent period. At the same time, fibrinogen was increased and blood sedimentation rate accelerated. (5) Examinations of the meulengracht's value of the blood serum as well as urine, bromsulphalein and phenolsulfonphthalein tests revealed, in many cases impairments of liver and renal functions for several days. (6) In 12 of 14 patients, in whom the examination of blood sugar were performed an increase in the blood sugar content occurred in the comatose stage, (7) The above-mentioned various changes paralleled the grade of seriousness of the illness, not the kinds of hypnotics.
- 千葉大学の論文