アノイリナーゼ菌に関する研究補遺
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概要
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The activity of fecal aneurinase is caused by the presence of the bacterium producing aneurinase which decomposes vitamin B_1 Whether one is diagnosed to be suffering from the ailment caused by aneurinase or merely to be a carrier of bacteria producing aneurinase depends upon the activity of this organism in the intestinal canal. B_1 avitaminosis caused by the presence of this organism has been identified as "enterogenous beriberi" which has come to attract attention from the hygienic and clinical standpoint, as it is a beriberi caused by organisms unlike the so called beriberi. Moreover, it is the subject of study by many investigators whether there exists any particular disposition for the ailment caused by aneurinase. Progress in this line of study, however, has been slow partly due to the fact that no report had ever been made on the etiological study of this condition in the natural animal world although several reports had been made by investigators throughout japan on the frequency of detection of the ailment caused by aneurinase and of the carriers of bacteria producing aneurinase in feces test. The author first performed checking up on the results of human feces test, and then investigated the presence of the ailment caused by aneurinase and the carriers of bacteria producing aneurinase in pigeons. The pigeonsused in the experiments consisted of the two groups: Those that were reared in natural environment and those that were fed on regular diet. In order to determine the relationship between the change in intestinal flora and the presence of bacteria producing aneurinase, the change in the bacterial content of the intestine of pigeons, was investigated. Experiments on pigeons fed on a diet consisting too exclusively of white rice were also carried out with a view to confirming this relationship. The results of the experiments are summarized as follows: 1) Investigation of the feces of 200 normal persons; disclosed that the frequencies of detection of the ailment caused by aneurinase and the carriers of bacteria producing aneurinase were 1.5 % (3 cases) and 8.0 % (16 cases), respectively. 2) The activity of fecal aneurinase was positive in 29 pigeons (8.3 %) out of 290 normal pigeons investigated. 3) 10 out of 11 pigeons fed on a diet consisting too exclusively of white rice developed conditions typical of " Hakumaibyo," a disease caused by a diet consisting tool exclusively of white rice. The activity of fecal aneurinase was positive in 5 of them, or 50 %. 4) The bacterium producing aneurinase detected showed biological and immunoserological properties more or less similar to those of B. M. M.. 5) Investigation of the intestinal flora of pigeons in which the activity of fecal aneurinase was positive revealed that, of all the coli bacteria, sucrosedecomposers accounted for the overwhelming majority as compared with nonsucrose-decomposers. 6) Investigation of the intestinal flora of the pigeons fed on a diet consisting too exclusively of white rice revealed that a predominance of sucrose-decomposers among coli bacteria had occurred in the majority of pigeons investigated. Among them, the frequency of the presence of pigeons in which the activity of fecal aneurinase was positive was high. 7) The results of the experiments as itemized above would evidencel that the predominance of sucrose-decomposers among the coli bacteria in the intestinal flora might be one of the factors responsible for the onset of the ailment caused by aneurinase and this phenomenon might heve something to do with a deficiency in vitamin B_1.
- 千葉大学の論文
- 1955-05-28
著者
関連論文
- 8. 長期ガス曝露実験用動物飼育装置の研究(第422回千葉医学会例会 衛生学公衆衛生学教室連合会)
- 14. アノイリナーゼ菌に関する知見補遺(I.一般演説,谷川教授開講十周年記念,第329回千葉医学例会,衛生学教室例会連合会演説要旨)
- アノイリナーゼ菌に関する研究補遺