疫痢に於ける血清コリンエステラーゼ活性値に就て
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概要
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Autopsy reveals that lesion of advanced degree develops in the liver in Ekiri (toxic dysentery of Japanese children). It has been reported that in Ekiri patients serous hepatitis with diffused fatty infiltration of liver cells is observed pathologically, whereas clinically liver function is impaired. On the other hand, determination of serum choline esterase values has recently come to be applied clinically as an index of liver function, for it is one of the most reliable means for testing liver function. In the present investigation, the author measured serum choline esterase activity in children suffering from dysentery and Ekiri with the object of examining whether their liver function was impaired. A biological method using musculus rectus abdominis of the frog was employed in the experiments. The findings are summarized as follows: 1) The serum choline esterase values measured in dysentery were found to be in normal range in majority of the cases studied, though in some cases they were lower than normal level. Their average values were 46 units in 10 minutes, 14 units in 20 minutes and 2 units in 30 minutes. The cases which showed slightlylower. values at the onset of disease have come to manifest normal values by the first week. 2) The serum choline esterase values measured in Ekiri were markedly lower than normal values in all the cases studied. Their average values were 79 units in 10 minutes, 57 units in 20 minutes, 37 units in 30 minutes, 23 units in 40 minutes, 15 units in 50 minutes and 10 units in 60 minutes. Observation of day to day variations in values in the cases which afforded an opportunity of doing so over a period of time disclosed that values rose to normal level by the first to second week, although some of them manifested further lowering during the period of observation. It will be seen as the result of the experiments indicates that the liver function remains normal in majority of the cases of dysentery, and, even though it is slightly mipaired, the recovery soon takes place. On the contrary, the liver function is impaired to a large degree in Ekiri and it is presumed that it takes considerably long period (about two weeks) to recover.
- 千葉大学の論文
- 1954-09-28
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- 疫痢に於ける血清コリンエステラーゼ活性値に就て