抗ヒスタミン剤に関する薬理学的研究 : 第I編剔出心臓,腸管等に於ける研究

概要

論文の詳細を見る
In the present investigations, the three compounds as Benadryl, 3015 R.P. and 3277 R.P. have been tested. 1. Antihistaminics did show not only a marked antagonistic action to histamine but also to acetylcholine. 2. Antihistaminics, combined with quinidine, did show a paralyzing effect on cardiac automaticity of the isolated frog heart. 3. The relative order of antihistaminic potency is as follows: 3277 R.P > 3015 R.P > Benadryl. 4. The relative order of antiacetylcholinic potency is as follows: Benadryl > 3277 R.P > 3015 R.P 5. The dose of antihistaminics which antagonize to acetylcholine was the same between pre- or post- treatment of acetylcholine. 6. The dose of antihistaminics which antagonize to histamine was different between pre- or post- treatment of histamine.
千葉大学の論文
1953-09-28