Analysis of the inhibitory mechanism of D-allose on MOLT-4F leukemia cell proliferation(MEDICAL BIOTECHNOLOGY)
スポンサーリンク
概要
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D-Allose, the C-3 epimer of D-glucose, is one of the rare sugars found in nature. In the present study, we have elucidated for the first time that various leukemia cell lines have different susceptibility to anti-proliferative activity of D-allose, and that this difference is related to the difference in induction of thioredoxin interacting protein (TXNIP) expression. We examined 5 leukemia cell lines (MOLT-4F, IM-9, HL-60, BALL-1 and Daudi), and found that MOLT-4F (T-cell lymphoblastic leukemia) had the highest susceptibility to D-allose, and that Daudi (Burkitt's lymphoma) had the lowest. D-Allose significantly slowed the cell cycle progression without causing apoptosis of MOLT-4F cells. Intracellular TXNIP expression was specifically and markedly enhanced in MOLT-4F cells by D-allose treatment, and subsequent increase of p27^<kip1>, a cell cycle inhibitor, was observed. On the other hand, D-allose did not increase TXNIP and p27^<kip1> levels at all in Daudi cells. These results indicate that D-allose suppresses MOLT-4F cell proliferation possibly by the inhibition of cell cycle progression via induction of TXNIP expression.
著者
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TOKUDA Masaaki
Department of Physiology, Faculty of Medicine, Kagawa Medical University
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Janjua Najma
Departments Of Biology The Kagawa Medical School
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Janjua Najma
Department Of Liberal Arts And Sciences Kagawa Prefectural College Of Health Sciences
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Tokuda Masaaki
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Masada Tetsuya
Department Of Gastroenterology And Neurology Kagawa University School Of Medicine
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DONG Youyi
Department of Physiology, Kagawa Medical University
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SUI Li
Department of Perinato-Gynecology, Faculty of Medicine, Kagawa Medical University
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KONISHI Ryoji
Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa Medical University
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Yamaguchi Fuminori
Department of Cell Physiology, Faculty of Medicine, Kagawa University
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Tsukamoto Ikuko
Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University
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Tokuda M
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Sui Li
Department Of Pharmaco-bio-informatics Faculty Of Medicine Kagawa University
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Sui Li
Department Of Nuclear Physics China Institute Of Atomic Energy
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Dong Youyi
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Saito Madoka
School Of Pharmaceutical Sciences Mukogawa Women's University
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Masaki Tsutomu
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Konishi Ryoji
Department Of Pharmaco-bio-informatics Faculty Of Medicine Kagawa University
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Kamitori Kazuyo
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Hirata Yuko
Department of Cell Physiology, Faculty of Medicine, Kagawa University
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Uehara Eisuke
Department of Cell Physiology, Faculty of Medicine, Kagawa University
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Uehara Eisuke
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Hirata Yuko
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Tsukamoto Ikuko
Department Of Pharmaco-bio-informatics Faculty Of Medicine Kagawa University
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Tsukamoto Ikuko
Department Of Anesthesiology And Emergency Medicine Kagawa Medical School
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Yamaguchi Fuminori
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Dong Youyi
Department of Cell Physiology, Faculty of Medicine, Kagawa University
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Sui Li
Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University
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Kamitori Kazuyo
Department of Cell Physiology, Faculty of Medicine, Kagawa University
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