Anti-aging effect of rice wine in cultured human fibroblasts and keratinocytes(BREWING AND FOOD TECHNOLOGY)
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概要
- 論文の詳細を見る
The application of rice wine on skin is known to have beneficial effects such as enhancement of the skin barrier function and skin whitening. In this study, we focused on examination of the anti-aging effects of rice wine. The treatment of fibroblasts with rice wine in vitro increased the expression of procollagen and laminin-5, a key basement membrane component in cultured human fibroblasts. Rice wine significantly reduced the expression of UV-induced matrix metalloproteinase-1(MMP-1) in a dose-dependent manner in both cultured human fibroblasts and keratinocytes. In addition, treatment with rice wine decreased UV-induced tumor necrosis factor-α(TNF-α) production in human keratinocytes. An in vivo study using hairless mice showed that topical application of rice wine protected mouse skin from photoaging. Thus, we suggest that rice wine may have potential as an effective agent for the prevention and treatment of UV-induced skin aging.
- 社団法人日本生物工学会の論文
著者
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Park Jung-keug
Department Of Biomedical Engineering Dongguk University:department Of Chemical And Biochemical Engin
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Park Jung-keug
韓国
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Seo Min-jae
Doosan R&d Center
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Park Jung-keug
Dep. Of Chemical And Biochemical Engineering Dongguk Univ. 3-26 Pil-dong Chung-gu Seoul 100-715 Kor
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Park Chang-seo
Department Of Chemical And Biochemical Engineering Dongguk University
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Seo Young-kwon
Department Of Pathology
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Kim Jin-wook
Doosan R&d Center
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Seo Miy-Young
Doosan R&D Center
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Chung So
Doosan R&D Center
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Choi Wang-Keun
Doosan R&D Center
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Jung Su-Hyun
Department of Chemical and Biochemical Engineering, Dongguk University
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Park Jung-Min
Doosan R&D Center
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Chung So
Doosan R&d Center
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Seo Young-kwon
Department Of Chemical And Biochemical Engineering Dongguk University
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Choi Wang-keun
Doosan R&d Center
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Jung Su-hyun
Department Of Chemical And Biochemical Engineering Dongguk University
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Park Jung-min
Doosan R&d Center
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Park Jung-keug
Dongguk Univ.
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CHUNG So-Young
Doosan R&D Center
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Seo Min-jae
Doosan R & D Center
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Park Jung-min
Doosan R & D Center
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Chung So
Doosan R & D Center
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Seo Miy-young
Doosan R & D Center
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Chung So-Young
Doosan R & D Center
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