抗菌性モノマーMDPB配合セルフエッチングシステムの歯髄刺激性とin vivoにおける接着界面

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This study examined the pulpal reactions to adhesive systems that employ a self-etching primer containing the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB), and evaluated its in vivo bonding ability by animal tests. Class V cavities were prepared on the buccal surfaces of the anterior teeth of beagle dogs and composite filling was performed using the self-etching primer containing 5% MDPB in combination with experimental fluoride-releasing bonding resin or commercial bonding resin. After 7, 30 or 75 days, the teeth were extracted and serial thin sections were prepared following fixation, demineralization, and resin-embedding. The sections were stained with hematoxylin and eosin, and the pulp response was histopathologically examined according to the criteria of ISO7405. In addition, after 7 days, the crown of the canine tooth restored with composites using 5 % MDPB-containing primer and experimental bonding resin was cut, and the ultrastructure of the resin-dentin interface was observed by transmission electron microscopy (TEM). Restoration with MDPB-containing primer either with experimental or commercial bonding resin resulted in no pulpal inflammation for all periods. TEM observation demonstrated integrity of the resindentin interface with the production of a 0.5-1 μm thick hybridized layer and obturation of dential tubules with resin. The results indicate that the self-etching system employing the antibacterial primer containing MDPB, which is utilized for commercial version Clearfil Mega Bond FA, shows excellent biocompatibility and produces an effective bond under in vivo conditions.
特定非営利活動法人日本歯科保存学会の論文
2006-08-31

抗菌性モノマーMDPB配合セルフエッチングシステムの歯髄刺激性とin vivoにおける接着界面

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