Pharmacological Analysis of Antigen-Induced Late Airway Response in Rats(Pharmacology)

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概要

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• The pharmacological and pathophysiological characteristics of rat antigen-induced late airway response (LAR) are not yet fully understood. In this study, the pharmacological properties of rat ovalbumin (OVA)-induced LAR and effects of the clinically used anti-asthmatic drugs salbutamol (β_2-agonist), ketotifen (antihista-mine), pranlukast (anti-leukotriene C_4/D_4/E_4), and prednisolone (steroid) were examined. In addition, a comparison was made of cell infiltration in bronchoalveolar lavage fluid (BALF) between immediate airway response (IAR) and LAR, and the edematous features of lung during LAR were also examined. Although infiltration of inflammatory cells into BALF was increased in both IAR and LAR, only the increase in eosinophils at 1, 3, and 6h during LAR were significantly higher than those during IAR. Although β_2-agonist, antihistamine, and anti-leukotriene C_4/D_4/E_4 exhibited no effects on rat LAR, steroid attenuated LAR and decreased eosinophil number in BALF. LAR and the percentage water content were both increased after antigen inhalation, suggesting that LAR is involved in pulmonary edema in rats. In conclusion, antigen-induced LAR was related to pulmonary edema and eosinophil infiltration rather than contraction of airway smooth muscle. This is the first comprehensive study of the profiles of rat antigen-induced LAR, and these analyses of LAR improve understanding of the diverse mechanisms underlying human asthmatic diseases.

• 公益社団法人日本薬学会の論文
• 2009-03-01

著者

• Miyagawa Naoki

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

• Miyagawa Naoki

  岐阜薬科大学 薬理学

• Miyagawa Naoki

  Department Of Pharmacology Gifu Pharmaceutical University

• Kato Toshinobu

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

• Shibata Tsutomu

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

• Tanaka Masaru

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

• IWASAKI Hidenori

  Central Pharmaceutical Research Institute, Japan Tobacco, Inc.

• WAKITANI Korekiyo

  Central Pharmaceutical Research Institute, Japan Tobacco, Inc.

• Iwasaki Hidenori

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

• Wakitani Korekiyo

  Central Pharmaceutical Research Institute Japan Tobacco Inc.

関連論文

• Two Pharmacological Phases in Antigen-Induced Immediate Airway Response in Rats(Pharmacology)
• The Effect of a Newly Synthesized Indazole Compound, TAS-3-124, on Experimental Autoimmune Disease(Pharmacology)
• Pharmacological Analysis of Antigen-Induced Late Airway Response in Rats(Pharmacology)

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