所謂極量的發熱療法ニ關スル研究 : 第2編臨牀的研究

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According to C. Richert, J. Surmont and P. Le Go there are four kinds of fever-cure which are applicable to the human body. They are: 1) inoculation de maladies infectieuses, 2) injections de vaccin, 3) procede chimiques and 4) procede physiqucs. An intravenous injection of gonococcus vaccine was first put into practice by Bruck, Somer, Nakano etc. based on the fact that it promotes the production of anti-body in the blood. Later it was applied for the first time as one of the best fever-cure by Yamazaki, P. Mulzer and E. Keining, Brusehettini, Klopp etc. The author has been engaged in the clinical investigation of the fever-cure by means of an intravenous injection of maximal doses of sensitised vaccine of gonococcus, colibacillus, or a mixture of both since 1933 with his co-workers and sometimes by himself. In 1936 the author published a paper in which he maintained that: 1) a successive injection of large doses (total dosage ca. 42.0cc, eight times on alternate days) of vaccines did not cause any serious reaction on the part of patients, 2) the fever-cure resulted not only in an alleviation of clinical symptoms, but also in the microscopical disappearance of gonococcus, 3) the usual complications of gonorrhoea were also cured by this treatment, 4) the combination of this treatment with local medical applications produced more satisfactory results, 5) it was sometimes effective even for acute urethral gonorrhoea, which was hitherto taken to be a contra-indication against an intravenous injection of gonococcus vaccine, and 6) an injection of colibaccillus vaccine was, therefore, superior in producing higher fever and more effective than the injection of gonococcus vaccine. Now it seems opportune to inquire into the author's premises closely. He wants to add many case reports and biological and physicochemical examinations of the blood of patients determined both praetherapeutically and posttherapeutically. The results obtained by the author are as follow: I. Morphological alteration of the blood of gonorrhoeal patients caused by fever-cure. Three patients received an intavenous injection of 0,35 to 0,4cc of a sensitised vaccine of gonococcus for the first time. The number of the injections was five to seven. The total dosage of vaccine was 7,5 to 10,0cc and the maximal temperature showed 40° to 40,6℃. Blood was taken from each patient periodically and the morphological alteration of the blood was examined. The measurement of the leucocytes was performed by meaus of Thoma-Zeiss's haemacytometer and that of the erythrocytes and thrombocytes was made by Lampert's thrombocytes pipette composed of "Athrombit B" by rule. The classification of the leucocytes was determined in spread out specimens under Pappenheim May-Grunwald-Giemsa's staining. i) The leucocytes decreased obviously at the period of a shiver or a rigor (averagely 30 minutes after the injection) but they increased gradually and it went up to a marked leucocytosis at the period of the reduction of fever. The leucocytosis continued till the following day and it was gradually so strengthened with the injection that in one case the number of leucocytes reached 50,000. ii) a) As to the classification of the leucocytes it was proved that the neutrophilous leucocytes, particularly their yonger form, increased so remarkably by the attack of fever as they occupied occasionally 95% of all leucocytes and decreased on the following day to nearly their usual number. b) The lymphocytes and the mononuclear leucocytes, on the contrary, decreased notably by the attack of fever and increased more than usual on the following day. c) The blood of gonorrhoeal patient shows, as a rule, a marked eosinophilia. The eosinophilous leucocytes decreased plainly with fever and increased noticeably with the reduction of fever, but they reached the usual number with recovery. d) The erythrocytes did not show any manifest change during the fever-cure, though it increased slightly after each injection. e) The thrombocytes decreased immediately after the injection, but they increased gradually and on the following day a slight thrombocytosis was detectable. II. Influence of the maximal fever-cure upon the gonococcus in the urethra. Three patients with a serious dischange of pus were given an intravenous injection of a sensitised vaccine of gonococcus three to four times. Pus taken from the urethral orifice at a fixed hour was spread out into specimens stained with Giemsa's solution and was compared under a microscope with that of a patient under almost the same condition without any injection (control). The phagocytic index was determined after Torikata and Suguro. The phagocytic index showed a marked ascension during fever sttack. It is a matter of course that the phagocytic index descends gradually with a decrease of gonococcus in pus by feverishness. The phagocytic index, however, during fever is always higher than that before fever and the index approaches zero with a decrease of gonococcus. In the control case, on the contrary, gonococcus in pus did not disappear or decrease for a long period of time, nor did the phagocytic index showed any notable oscilation. III. Influence of the maximal fever-cure upon haemoglobin contents. The patients received an intravenous injection of sensitised vaccine of colibacillus or gonococcus successively on alternate days, the number of injections being three and the total dose of vaccine being 1.9 to 3.5cc. Blood was taken after the first injection periodically and the haemoglobin contents were measured by means of Sahli's Haemoglobinometer. i) There was not any noticeable change of haemoglobin contents caused by the fever-cure. ii) The haemoglobin contents of gonorrhoeal patients did not differ much from that of healthy person. IV. Influence of the maximale fever-cure upon the capability of resistance of the erythrocytes. Seven patients were given an intravenous injection of colibacillus vaccine in three doses totaling 2.1 to 4.0cc and three patients received an intravenous injection of gonococcus vaccine in three doses totaling 4.5 to 5.8cc. Blood was taken from each patient before and after every injection and the capability of the resistance of the erythrocytes against hypotonic salt solution was examined by rule. The resistance of the erythrocytes after the injection of either vaccine did not differ much from that before injection in general. V. Influence of the maximal fever-cure upon descending velocity of the erythrocytes. Seven patients received an intravenous injection of colibacillus vaccine in three doses totaling 2.1 to 4.0cc and three patients got an intravenous injection of gonococcus vaccine in three doses totaling 3.3 to 4.6cc. Blood was taken from each patient before and after every injection and the descending velocity of the erythrocytes was measured after Westergreen at nearly 20℃. Although there was a slight individual difference, the descending velocity increased generally with the injection of either vaccine and it was promoted by the injection. VI. Influence of the maximal fever-cure upon the blood coagulation. Seven patients received an intravenous injection of colibacillus vaccine in three doses totaling 1.6 to 4.0cc and three patients got an injection of gonococcus vaccine in three doses totaling 2.9 to 5.5cc. The duration requrired for coagulation of blood of each patient was determined with a coagulometer after Blodie-Rossel-Boggs under conditions as same as possible. The duration required for the blood coagulation at the period of fever attack was 1.5 to 3.2 minutes longer than that before injection. VII. Influence of the maximal fever-cure upon the concentration of hydrogen ions of blood-serum. 2.1 to 4.9cc of colibacillus vaccine was given to seven patients intravenously and 3.0 to 4.5cc of gonococcus vaccine to three patients in the same way. Blood was taken from each patient before and after the injection and the concentration of hydrogen ions of isolated serum was examined by means of Wulff's colorimeter. It was proved that the concentration of hydrogen ions at the period of fever attack always slightly increased. VIII. Influence of the maximal fever-cure upon the surface tension of blood-serum. Six patients received an intravenous injection of colibacillus vaccine in three oses totaling 1.6 to 3.5cc and four patients received an injection of gonococcus vaccine in three doses totaling 2.5 to 5.5cc successively. Blood was taken from each patient before and after the injection and the surface tension of fresh serum was determined by means of a tensiometer after P.L. du Nouy with great care not to make possible errors. It was confirmed that there was no manifest change of the surface tension of blood-serum caused by fever. IX. Influence of the maximale fever-cure upon the viscosity of blood-serum. 1.8 to 4.9cc of colibacillus vaccine was given to seven patients intravenously and 2.8 to 4.6cc of gonococcus vaccine was given to three patients intravenously. Blood was taken from each patient before and after the injection and the viscosity of blood-serum was examined with a Hess's viscosimeter using the utmost discretion. It was found that the viscosity of some serum showed a slight tendency to increase after the injection, but the average worth did not differ much from that before injection. X. Influence of the maximal fever-cure upon the colloid stability of blood-serum. Eight patients received an intravenous injection of colibacillus vaccine in three doses totaling 1.8 to 4.9cc and two patients were given intravenously in three doses totaling 4.5 to 4.9cc of gonococcus vaccine. Blood was taken before and after the injection and the colloid stability of blood-serum was tested under Daranyi's method. It was proved that the colloid stability of blood-serum was generally strengthened by the injection, though it happened to show an individual difference.
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所謂極量的發熱療法ニ關スル研究 : 第2編臨牀的研究

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所謂極量的發熱療法ニ關スル研究 : 第2編 臨牀的研究

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所謂極量的發熱療法ニ關スル研究 : 第2編臨牀的研究