いんしゆりんノ經皮吸收ニ就テ

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The author made an examination of peicutaneous absorption by determining the value of blood-sugar in rabitts by using insulin (Lily) as an indicator. Method of examination. The hair on the ablominal part (10×14cm) of healthy adult male rabitts of approximately 2kg was cut with scissors as closely as possible and care was taken so as not to make any wound detectable with a mngnifying-glass. Thirty four rabitts, whose value of blond-sugar had previoasly been determined, were divided into ten groups. 1) Five units of insulin per kg body weight were admixed with physiologic salt solution to produce 5cc of mixture. The experimental parts of the rabits belonging to the first group was slightly rubbed with the solution, using one's right forefinger covered with gum-cap. 2) One-third unit of insulin per kg was injected subcutaneously into the backs of the rabits belonging to the second group. 3) One unit of insulin per kg was injected subcutaneously into the backs of the rabbits belonging to the third group. 4) The experimental parts were slightly rubbed several times with cotton saturated with 5cc of petroleum-beazine, and cleaned by poaring a physiologic salt solution thereoa. After this preliminary treatment, rabbits belonging to the fourth group received the Same application as stated in (1). 5) After the preliminary treatment mentioned above, the experimental parts of the rabbits belonging to the fifth group received the same application as stated in (1). In this case, however, insulin was admixed with triaethanolamin instead of a physiological salt solution. 6) Twenty units of insulin per kg were admixed with physiologic salt solution so as to form 10cc of mixture. This mixture was rubbed on the experimental parts of rabbits belonging to the sixth group in the same way as described in (1), after the preliminary treatment. 7) Twenty units of insulin per kg were admixed with triaethanolamin instead of physiologic salt so as to produce 10cc of mixture. This mixture was rubbed on the experimental parts of rabbits belonging to the seventh group in the same way as described in (1), after the preliminary treatment. 8) The units of insulin per kg were admixed with physiologic salt solution so as to produce 5cc of mixture. This was rubbed an the experimental parts of rabbits belonging to the eighth group in the same way as cited in (1), after the preliminary treatment. The abdominal part of each rabbit then received a fomentation consisting of a mixture of insulin and physiologic salt solution in the ratio noted at the beginning of (8) for sixty minutes, the same being administered with absorbent cotton of determined area and weight. 9) Rabbits belonging to the ninth group received the same treatment as described in (8); but triaethanolamin instead of physiologic salt solution was used. 10) Rabbits belonging to the tenth group received no treatmeut. Following the injections of solutions blood was taken out of the ear-vein of each rabbit at the end of each hour for six hours and the value of blood-sugar was determined by the Hagedorn-Jensen method. The following results were obtained: 1) The value of blood-sugar did not decrease in the groups without preliminary treatment. 2) One rabbit belonging to the fourth group showed a decrease in the value of blood-sugar, while that of the others remained unchanged. 3) Three rabbits belonging to the sixth group showed a noticeable decrease in the value of blood-sugar, while blood-sugar value of one remained unchauged. 4) Two rabbits belonging to the eighth group showed a more remarkable decrease in the value of blood-sugar than・those belonging to the sixth group, while that of two others remained practieally unchanged. 5) The value of blood-sugar of the rabbits belonging to the fifth group remained practically constant. 6) One rabbit belonging to the seventh group showed a noticeable decrease in the value of blood-sugar, while that of three others remained unchanged. 7) One rabbit belonging to the ninth group showed a more remarkable decrease in the valve of blood-sugar than those belonging to the fifth group, while that of the others remained unchanged. 8) Percutaneous absorption seemed, therefore, to be promoted by fomentation. Triaethanolamin, however, did not seem to act favorably an percutaneous absorption in this experiment. 9) Rabbits belonging to the second and third groups seemed uneasy and spasmodic during the examination and some even died. Such a state of condition did not occur in rabbits rubbed with insulin. The author was unable, after all, to prove the percutaneous absorption of insulin clinically. 10) Insulin can be absorbed percutaneously under favorable conditions. The amount, however, is not constant and varies much individually.
京都府立医科大学の論文

著者

谷川一馬
京都府立醫科大學

いんしゆりんノ經皮吸收ニ就テ

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