The Role of an LMO2/TAL1 (SCL)/GATA complex in definitive hematopoiesis
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概要
- 論文の詳細を見る
The basic helix-loop-helix transcription factor Tall (Scl), the LIM-finger protein Lmo 2, and the GATA-finger proteins Gata1/2/3 have important roles in hematopoiesis. Genetic disruption of Tall (Scl) and Lmo2 individually results in defective yolk sac erythropoiesis and definitive hematopoiesis. These transcription factors physically interact with each other to form an Lmo2/Tall/Gata1/2/3 transcription factor complex. In order to know whether these transcription factors form a complex to play critical roles in hematopoiesis, mutant Lmo2s were made to specifically disrupt the interaction between Lmo2 and Gata1/2/3 by introducing a mutation in the LIM 2 domain of Lmo2. Overexpression of these mutant Lmo2s in mice severely impaired fetal liver hematopoiesis and thymus development, indicating its role as a master complex for the development of the entire hematopoietic system. In this complex, Lmo2 functions as an adapter molecule and cell-autonomously determines the fate of each blood cell to either erythroid or lymphoid cell by recruiting Gata1/2/3 at different stage of hematopoietic differentiation.
- 藍野大学の論文
著者
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Yamada Yoshihiro
Faculty Of Nursing And Rehabilitation Aino University
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Yamada Yoshihiro
Faculty Of Agriculture Kagawa University
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