ビタミンEサプリメントの連続摂取による血漿中トコフェロール濃度の変化 : 複合型トコフェロール製剤とα-トコフェロール製剤の比較

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We investigated the effects of mixed vitamin E supplement and α-tocopherol supplement on the plasma tocopherol levels in Japanese subjects. Two groups of volunteers were enrolled. The mixed vitamin E group (mix E group)(n=18) received mixed vitamin E capsules (Total-toc 300mg/day, α-Toc:γ-Toc:other tocopherols=150:100:50) for 4 weeks, while the other group (α-Toc group) (n=17) received α-Toc capsules (Total-toc 300mg/day, α-Toc:γ-Toc:other tocopherols=300:0:0) As a result, plasma total-Toc concentration increased markedly during administration in both groups, but there was no significant between groups. Also the plasma α-Toc concentration in both groups went up significantly, and the α-Toc group was significantly higher than the mix E group. On the other hand, the plasma γ-Toc concentration increased significantly in the mix E group, and it decreased significantly in the α-Toc group. Our data suggested that the mixed vitamin E supplement made the total-Toc concentration increase, keeping a tocopherol balance (ratio of the four tocopherol concentrations) in plasma.
2009-01-25