マウスの寒冷ストレスに対するd-リモネンの抑制効果
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概要
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The effects of d-limonene on the concentrations of corticosterone in mouse plasma were studied by using a cold stress model. The concentrations of corticosterone in the plasma of mice loaded with the cold stress at 4℃ for 30 minutes were ca. 3.4 times as higher as those of the control mice. When mice were loaded with the cold stress in the atmosphere including 50, 100, 150 μL of d-limonene/ca. 11 L, the concentrations of corticosterone in mouse plasma tended to be decreased depending on the amount of d-limonene. Especially, the concentrations of corticosterone in the plasma of mice treated with 100 μL of d-limonene were significantly lower than those of mice loaded with the cold stress only, and there was no significant difference between the concentrations in mice treated with 150 μL of d-limonene and those of the control mice. These results suggest that the inhalation of d-limonene could lower the concentrations of corticosterone in the plasma of mice loaded with the cold stress and the preventing effects of this compound on the cold stress would be expected.
- 沼津工業高等専門学校の論文
- 2008-01-31