Research Overview of the Lab. of Molecula Biology, Tohoku University Graduate School of Agricultural Science(Recent Topics of the Agricultunal Biological Science in Tohoku University)
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概要
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In our laboratory, mainly three different projects described below are now carried out. 1) "Generation and application of the cell membrane permeabilized protein", 2) "Studies on epigenetic regulation of eukaryotic genes through analyses of actin-related proteins" and 3) "Generation of the oxytocin receptor KO (OXTR-/-) mice, and molecular physiological and behavioral analysis of the oxytocin receptor KO (OXTR-/-) mice." In the first project, we generated recombinant Cre protein fused to TAT PTD (protein transduction domain), and the application of this protein into several primary cells prepared from mouse, showed significant recombinase activity. In the second project, we studied epigenetic regulation of eukaryotic genes through analyses of actin-related proteins. In the third project, we obtained several new findings in reproduction, sociosexual behaviors and in physiology of energy/temperature homeostasis of mice as the functions of oxytocin/oxytocin receptor system in vivo, using the oxytocin and its receptor genes deficient (OXT-/- and OXTR-/-) mice. Here we introduce a little about those three projects, respectively.
- 東北大学の論文
著者
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Hidema Shizu
Lab. Of Molecular Biology Dep. Of Molecular And Cell Biology Graduate School Of Agricultural Sci. To
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Hidema Shizu
Lab. Of Mol. Biol. Graduate School Of Agric. Science Tohoku University
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Harata Masahiko
Lab. Of Mol. Biol. Graduate School Of Agric. Science Tohoku University
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NISHIMORI Katsuhiko
Lab. of Mol. Biol. Graduate School of Agric. Science, Tohoku University
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Hidema Shizu
Laboratory Of Molecular Biology Department Of Molecular And Cell Biology Graduate School Of Agricult
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Nishimori Katsuhiko
Lab. Of Mol. Biol. Graduate School Of Agric. Science Tohoku University
関連論文
- Research Overview of the Lab. of Molecula Biology, Tohoku University Graduate School of Agricultural Science(Recent Topics of the Agricultunal Biological Science in Tohoku University)
- Generation of Adeno-Associated Virus Vector Enabling Functional Expression of Oxytocin Receptor and Fluorescence Marker Genes Using the Human eIF4G Internal Ribosome Entry Site Element
- Effects of protein transduction with intact myogenic transcription factors tagged with HIV-1 Tat-PTD (T-PTD) on myogenic differentiation of mouse primary cells(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Effects of protein transduction with intact myogenic transcription factors tagged with HIV-1 Tat-PTD (T-PTD) on myogenic differentiation of mouse primary cells
- Impairment of Pachytene Spermatogenesis in Dmrt7 Deficient Mice, Possibly Causing Meiotic Arrest