Preparation and Prodrug Studies of Quercetin Pentabenzensulfonate

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概要

• 論文の詳細を見る

• Pentabenzensulfonate (QPBS), a potential prodrug for quercetin, was designed and synthesized in high yield. It possesses better physical properties such as solubility, lipid/water partition coefficient, LogP, and hydrolysis kinetics than its original form. The LogP value (2.04) and the half-life of the hydrolysis value (3.85h) show that oral bioavailability is improved evidently compared with that of quercetin. These results indicate that QPBS can be considered as a potential prodrug for quercetin.

• 公益社団法人日本薬学会の論文
• 2008-12-01

著者

• Peng You

  State Key Laboratory Of Food Science And Technology Nanchang University:department Of Chemistry And

• Deng Zeyuan

  State Key Lab Of Food Science And Technology Institute For Advanced Study Nanchang University

• Deng Zeyuan

  State Key Laboratory Of Food Science And Technology Nanchang University

• Wang Chunfeng

  Department Of Chemistry And Engineering Jiujiang University

• Peng You

  State Key Lab Of Food Science And Technology Institute For Advanced Study Nanchang University

関連論文

• Isolation and purification of three flavonoid glycosides from the leaves of Nelumbo nucifera (Lotus) by high-speed counter-current chromatography
• Preparation and Prodrug Studies of Quercetin Pentabenzensulfonate

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