日本の少子化対策としての着床前診断所見 : 染色体数的異常に起因する習慣流産に対する着床前診断の適応に期待する

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Since 1998, the Japan Society of Obstetrics and Gynecology has placed severe restraints on preimplantation genetic diagnosis of embryos (PGD). However, finally (in 2006), the Society approved the clinical application of PGD to habitual abortion due to structural chromosomal abnormalities as well as to serious genetic diseases such as Duchenne muscular dystrophy (DMD) and myotonic dystrophy. But, it has not yet approved the clinical application of PGD to habitual abortion due to numerical chromosomal abnormalities, although the number of these patients is much greater than the number of patients suffering from habitual abortion due to structural chromosomal abnormalities.The reason why the Society still places severe restraints on PGD is because it bases its opinion on the following paper. (Sugiura-Ogasawara M, Ozaki Y, Sato T, Suzumori N, Suzumori K: Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations. Fertil. Steril. 81:367-373, 2004.)Dr. Otani and his representative criticize the Japan Society of Obstetrics and Gynecology for basing its opinion on a paper that presents a faulty data interpretation. Nevertheless, the Japan Society of Obstetrics and Gynecology remains absolutely silent and does not counter this criticism.In this paper, I will anticipate the clinical application of PGD to habitual abortion due to numerical chromosomal abnormalities.