異なる脂肪酸組成の高脂肪食摂取がラット骨格筋のミトコンドリア酵素活性およびPGC-1α蛋白含量に及ぼす影響

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The purposes of this study were 1) to examine whether fatty acid composition of the diet might affect mitochondrial enzyme activities in rat skeletal muscle, and 2) to assess the effects of the high-fat diets on skeletal muscle peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α) protein content, which is a key regulator of adaptive mitochondrial biogenesis. Four-week-old male Sprague-Dawley rats were fed for 30 days either a rodent chow (12% calorie from fat, CON group; n=5) or a high-fat diet (50% calorie from fat) containing lard (LARD group; n=5) or olive oil (OLIVE group; n=5). Citrate synthase (CS) and 3-hydroxyacyl-CoA dehydrogenase (3-HAD) activities in plantaris muscles were significantly higher in both LARD and OLIVE groups than CON group (p<0.05). Furthermore, the 3-HAD activity in OLIVE group was significantly higher than that in LARD group (p<0.05). PGC-1α protein contents in epitrochlearis muscle were significantly higher in both LARD and OLIVE groups than CON group by 88 and 70%, respectively(p<0.05). No significant difference in PGC-1α protein content was observed between LARD and OLIVE groups. In conclusion, these results indicate that 1) olive oil, which consists mostly of unsaturated fatty acids, has more pronounced effects on the fatty acid oxidation enzyme activity in skeletal muscle, compared with lard enriched in saturated fatty acids, and 2) feeding high-fat diets increases transcription coactivator PGC-1α protein content in rat skeletal muscle.
日本運動生理学会の論文
2008-11-20

異なる脂肪酸組成の高脂肪食摂取がラット骨格筋のミトコンドリア酵素活性およびPGC-1α蛋白含量に及ぼす影響

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