EFFECTS OF EXPERIMENTALLY INDUCED ALLERGIC RHINITIS ON THE MOUSE OLFACTORY SYSTEM : ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES

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Allergic rhinitis often causes olfactory dysfunction. However in patients with allergic rhinitis, olfactory dysfunction prolonged even after nasal obstruction improves, suggesting another mechanism involved in olfactory dysfunction. We made mice model of allergic rhinitis with the possibility of olfactory dysfunction using ovalbmin, and evaluated olfactory function by electrical local field potential in olfactory bulb and histological changes in the olfactory mucosa. Local field potential demonstrated an attenuation of the theta activity in the allergic rhinitis mice, indicating impairment of the olfactory sensation. Histopathology showed more prominent infiltration of eosinophils, macrophage and plasma cells, and with an increase of mucin in lamina propria. This mouse model could provide an expedient system for analyzing mechanisms of neurologenic olfactory dysfunction.
名古屋市立大学の論文