水溶性フラボノイド配糖体αG-ルチンの消化管吸収機構

概要

論文の詳細を見る
Flavonoids are polyphenols that are found in many foods and which function as antioxidants in the body. However, the mechanisms for absorption of polyphenolic compounds remain unclear. The recently-manufactured quercetin glycoside αG-rutin is a water-soluble glucose adduct of rutin (quercetin-3-β-glucosyl-rhamnose) and this compound is 1,000 times dissolubility is higher than rutin. This review describes how the intestinal absorption and metabolism of αG-rutin in vivo, in situ and in vitro. αG-rutin is transported through the intestinal mucosa both in vivo and in vitro, and demonstrated that a considerable proportion of the αG-rutin was absorbed as the intact glycoside via the paracellular pathway. In addition, αG-rutin is absorbed more efficiency than either quercetin or rutin and that a high plasma concentration can be maintained by supplying rutin αG-rutin in combination in in vivo study. Thus, αG-rutin will be an effective source of quercetin and expected to be beneficial as antioxidant for human health.
2008-03-31