劇症肝炎・LOHFに対するHigh-Volume Hemofiltration (HVH)治療と不死化ヒト肝細胞開発

概要

論文の詳細を見る
Methods of treatment for survival in fulminant hepatitis/LOHF were analyzed from the national survey. Improvement of survival rates of fulminant hepatitis/LOHF needed liver transplantation in addition to artificial liver support. Hemodiafiltration (HDF) and on-line HDF remarkably improved waking from hepatic coma. Although high-volume hemofiltration (HVH) also improved recovery of fulminant hepatitis/LOHF and reduced the rate of liver transplantation, HVH prolonged the time of liver transplantation from the onset of hepatic coma and decreased the survival rate of liver transplantation. Immortalized human adult hepatocytes which were lentivirally transduced with HPV 16 E6/E7 and hTERT, named HHE 6E 7 T-1 cells, proliferated in culture beyond 200 population doublings (PDs). Intrasplenic transplantation of HHE 6E 7 T-1 cells over 200 PDs significantly improved the survival of acetaminophen-induced acute liver failure SCID mice.
日本アフェレシス学会の論文
2008-10-31