Inhibition of the Epstein-Barr Virus Lytic Cycle by Andrographolide(Microbiology)

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概要

• 論文の詳細を見る

• Andrographis paniculata NESS is a medicinal plant that is commonly used in Asia. This work demonstrates that 25μg/ml of ethanolic extract from A. paniculata (EEAP) and 5μg/ml of andrographolide, a bioactive compound in EEAP, effectively inhibit the expression of Epstein-Barr virus (EBV) lytic proteins, Rta, Zta and EA-D, during the viral lytic cycle in P3HR1 cells. Transient transfection analysis revealed that the lack of expression of Rta, Zta and EA-D is caused by the inhibition of the transcription of BRLF1 and BZLF1, two EBV immediateearly genes that encode Rta and Zta, respectively. This study finds that the inhibition prevents the virus from producing mature viral particles. Meanwhile, andrographolide is not toxic to P3HR1 cells when the concentration is below 5μg/ml, indicating that the compound is potentially useful as an anti-EBV drug.

• 公益社団法人日本薬学会の論文
• 2008-11-01

著者

• Chang Li-kwan

  Institute Of Microbiology And Biochemistry National Taiwan University

• Duh Pin-der

  Department Of Food Science And Technology Chia-nan University Of Pharmacy And Science

• Duh Pin-der

  Department Of Food Health Chia Nan University Of Pharmacy And Science

• Chen Shih-ying

  Institute Of Nutrition And Health Science Chia-nan University Of Pharmacy And Science

• Liu Yen-ni

  Department Of Biotechnology Chia-nan University Of Pharmacy And Science

• LIN Tsuey-Pin

  Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science

• Lin Tsuey-pin

  Department Of Health And Nutrition Chia-nan University Of Pharmacy And Science

関連論文

• Pro-oxidative Properties of Flavonoids in Human Lymphocytes(Food & Nutrition Science)
• Inhibition of the Epstein-Barr Virus Lytic Cycle by Andrographolide(Microbiology)
• Antimutagenic Effect of Methanolic Extracts from Peanut Hulls

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