Synthesis, Structure Analysis and Cytotoxicity Studies of Novel Unsymmetrically N,N'-Substituted Ureas from Dehydroabietic Acid

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概要

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• A series of novel unsymmetrically N,N'-substituted ureas were synthesized from dehydroabietic acid and their structures were characterized by IR, ^1H-NMR, ^<13>C-NMR spectroscopy and single crystal X-ray diffraction. Three six-membered rings of urea 4c exhibited plane, half-chair and chair configurations, respectively. Their cytotoxicity activities against SMMC7721 liver cancer cells were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results showed that the title compounds exhibited highly effective cytotoxicity activities against SMMC7721 cells. Their IC_<50> values are between 8.8 and 14.2μmol/l. The change of N' substituted groups resulted little difference to the cytotoxicity activities of ureas, which indicated that the cytotoxicity of this kind of ureas depend strongly on the tricyclic hydrophenanthrene structure.

• 公益社団法人日本薬学会の論文
• 2008-11-01

著者

• He Ling

  Department Of Chemistry Zhejiang University

• He Ling

  Department Of Pharmacology China Pharmaceutical University

• He Ling

  Department Of Pharmaceutics School Of Pharmacy Shenyang Pharmaceutical University

• RAO Xiaoping

  Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry

• SONG Zhanqian

  Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry

• JIA Weihong

  Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry

• Rao Xiaoping

  Institute Of Chemical Industry Of Forest Products Chinese Academy Of Forestry

• Song Zhanqian

  Institute Of Chemical Industry Of Forest Products Chinese Academy Of Forestry

• Jia Weihong

  Institute Of Chemical Industry Of Forest Products Chinese Academy Of Forestry

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• Anti-proliferative effects and induction of apoptosis by liquiritigenin in human hepatocellular carcinoma SMMC-7721 cells
• Crystal Structure of the 1:2:2 Adduct of Piperazine, o-Phthalic Acid and Water
• Synthesis, Structure Analysis and Cytotoxicity Studies of Novel Unsymmetrically N,N'-Substituted Ureas from Dehydroabietic Acid
• Involvement of Mitochondrial Pathway in Triptolide-Induced Cytotoxicity in Human Normal Liver L-02 Cells(Pharmacology)
• Anti-proliferative effects and induction of apoptosis by liquiritigenin in human hepatocellular carcinoma SMMC-7721 cells

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