Immune Response of Gnotobiotic Piglets against Mycoplasma hyopneumoniae(Immunology)
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概要
- 論文の詳細を見る
In this study, several cytokine responses were investigated during Mycoplasma hyopneumoniae (Mhp) infection using a gnotobiotic infection model. We found that several inflammatory cytokines (IL-1β, IL-8, IL-18, and TNF-α) and an anti-inflammatory cytokine IL-10 were induced from peripheral blood mononuclear cells (PBMC) of germ-free (GF) piglets stimulated with heat killed Mhp whole antigens, but no IFN-γ and IL-4 were induced by Mhp. After the intranasal infection of Mhp, IL-Iβ, IL-18, and IFN-γ were also detected in the broncho-alveolar lavage fluids (BALF). The antigen-specific IFN-γ and IL-10 responses after infection of Mhp were gradually suppressed during Mhp infection as well as non-specific immune response to concanavalin A (ConA) and lipopolysacchalide (LPS) at early stage of infection. These results suggested that Mhp infection modulates the immune response of pigs by inducing several cytokines, and causes immuno-suppression of pigs in a gnotobiotic condition.
- 2008-10-25
著者
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Hikono Hirokazu
Research Team for Advanced Biologicals, National Institute of Animal Health
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MUNETA Yoshihiro
Research Team for Advanced Biologicals,National Institute of Animal Health
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MINAGAWA Yu
Research Team for Advanced Biologicals,National Institute of Animal Health
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SHIMOJI Yoshihiro
Research Team for Advanced Biologicals,National Institute of Animal Health
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OGAWA Yohsuke
Research Team for Advanced Biologicals,National Institute of Animal Health
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MORI Yasuyuki
Research Team for Paratuberculosis,National Institute of Animal Health
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Minagawa Yu
Research Team For Advanced Biologicals National Institute Of Animal Health
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Ogawa Yohsuke
Research Team For Advanced Biologicals National Institute Of Animal Health
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Mori Yasuyuki
Research Team For Paratuberculosis National Institute Of Animal Health
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Hikono Hirokazu
Research Team For Advanced Biologicals National Institute Of Animal Health
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Muneta Yoshihiro
Research Team For Advanced Biologicals National Institute Of Animal Health
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Shimoji Yoshihiro
Research Team For Advanced Biologicals National Institute Of Animal Health
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