Selection of Postoperative Systemic Chemotherapy for Advanced Gastric Cancer Patients with Hepatic Metastasis Using the Histoculture Drug Response Assay

スポンサーリンク

概要

• 論文の詳細を見る

• The usefulness of histoculture drug response assay (HDRA) before the start of antitumor chemotherapy was explored to predict the antitumor response of chemotherapy for progressive gastric cancer patients with hepatic metastasis. Cancer tissue was collected from 6 advanced gastric cancer patients with hepatic metastasis, to assess whether the tumor is sensitive to chemotherapeutic agents of 5-fluorouracil (5-FU), mitomycin C (MMC), docetaxel hydrate (TXT), and cisplatin (CDDP) by the HDRA method. The size of hepatic tumor was measured by CT scan 3 and 6 months after the start of the chemotherapy and examined the relationship between the selected chemotherapy and antitumor response. Of 6 patients investigated in the present study, 3 patients received monotherapy with TS-1[○!R], which was found to be effective in 2 patients (66.7%). In the patient who received MMC monotherapy, the HDRA showed the cancer tissue to be less sensitive to any of antitumor agents tested, resultantly indicating no antitumor response. In the remaining 2 patients with combination therapy with TS-1[○!R] and MMC, the selected chemotherapeutic agents showed anti-tumor effect. The HDRA is useful to predict the antitumor response of postoperative adjunctive chemotherapy for advanced gastric cancer patients with hepatic metastasis, and plays an important role in selection of antitumor agents.

著者

• Fukui Hirokazu

  獨協医科大学 病理学(人体分子)

• Katsumata Daisuke

  First Department Of Surgery Dokkyo Medical University School Of Medicine:department Of Surgical And

• Fukui Hirokazu

  First Department Of Surgery Dokkyo Medical University School Of Medicine:department Of Surgical And

• Sasaki Kinro

  First Department of Surgery, Dokkyo Medical University School of Medicine

• Miyachi Kazuhito

  First Department of Surgery, Dokkyo Medical University School of Medicine

• Sasaki Kinro

  First Department Of Surgery Dokkyo Medical University School Of Medicine:department Of Surgical And

• Miyachi Kazuhito

  First Department Of Surgery Dokkyo Medical University School Of Medicine:department Of Surgical And

関連論文

• Selection of Postoperative Systemic Chemotherapy for Advanced Gastric Cancer Patients with Hepatic Metastasis Using the Histoculture Drug Response Assay
• Genetic analysis of a local recurrent tumor after colonic polypectomy
• Immunohistochemical expression of cyclooxygenase (COX)-2 in colorectal adenomas
• Depth of Tumor Invasion in Locally Advanced Rectal Cancer Correlates with Patients' Prognosis : The Usefulness of Elastic Stain for Its Measurement
• Incidence of P53 and K-ras alterations in ovarian mucinous and serous tumors
• Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer : a Japanese collaborative study
• Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma
• Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients

スポンサーリンク