Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma

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概要

• 論文の詳細を見る

• Angiogenesis is a key process in tumor growth and metastasis. In 27 patients with advanced gastric carcinoma before operation and 9 healthy controls, plasma levels of endostatin (ES), cathepsin L (Cat-L) and soluble VEGF R1/Flt-1 (sVEGF R1), which are known to suppress angiogenesis, tumor growth and metastasis, were measured by ELISA in order to examine the clinical importance of the agents. In addition, expression of CD34, ES and Cat-L in tissues of the gastric carcinoma was investigated immunohistochemically in order to elucidate the correlation with the above plasma levels. Plasma ES levels in gastric carcinoma patients were significantly higher than those in controls (p=0.001). Plasma Cat-L levels in controls were slightly lower, though not significantly (p=0.065), than those in carcinoma patients. There was no significant difference in sVEGF R1 levels between gastric carcinoma patients and controls. Expression of ES and Cat-L in tumor tissues was positively associated with plasma sVEGF R1 levels. Expression of CD34 in tumor tissues was not found to be associated with any plasma markers. Our results suggested that plasma ES levels are elevated in gastric carcinoma and may be useful markers for gastric carcinoma.

• 獨協医科大学の論文
• 2006-03-25

著者

• Miyachi Kazuhito

  First Department Of Surgery Dokkyo Medical University School Of Medicine:department Of Surgical And

• Miyachi Kazuhito

  First Department Of Surgery Dokkyo University School Of Medicine

• Ohkawa Tetsuya

  First Department Of Surgery Dokkyo University School Of Medicine

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