新規院内製剤ネオ・ブロー氏液の臨床効果および調製上の留意点

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Burow's solution, a hospital preparation, exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and other microorganisms that are commonly observed in chronic supprative otitis media. However, it takes several days to prepare Burow's solution by the method commonly employed in Japan and it is difficult to ensure constant quality. With this in mind, we examined the pharmaceutical and pharmacological characteristics of Burow's solution and developed a new prescription for it (Neo-Burow's solution) having an aluminum acetate base. The new prescription takes only a few hours to prepare, is convenient, and ensures a solution of constant quality. In this study, we examined the clinical effects of Neo-Burow's solution in external and internal otitis. We prepared Neo-Burow's solution in the Department of Pharmacy and used it for 13 patients in whom commercially available antibiotics had had no effect, in the Department of Otorhinolaryngology of Hiroshima University Hospital. Nine of the patients completely recovered after treatment with Neo-Burow's solution, and it had some effect in 1 patient but was completely ineffective in the remaining 3 patients. No adverse reactions were observed. Our results indicated that Neo-Burow's solution was effective and safe in the treatment of chronic suppurative otitis, even that accompanied by MRSA. We have received a lot of inquiries about Neo-Burow's solution from pharmacies and other hospital facilities, most of them relating to its preparation and preservation. Our manuscript includes a summary of the in-quiries and the answers given to them.
日本医療薬学会の論文
2008-10-10

新規院内製剤ネオ・ブロー氏液の臨床効果および調製上の留意点

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